Prof. Dr. med. Wolfgang Kromer
         Specialist in Pharmacology and Toxicology            Specialist in Clinical Pharmacology

CONGRESS CONTRIBUTIONS

Kromer, W., J. Bläsig, A. Westenthanner, I. Haarmann, H.J. Teschemacher. Characteristics of porcine pituitary peptides which act like opiates: Release from anterior lobes in vitro - relation between central effects and degradation by brain enzymes. International Narcotic Research Club, Aberdeen, Scotland, July 19-22, 1976

Kromer, W., C. Fischer, L. Magner, E. de la Gala. Release of endorphins from various tissue extracts. Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, March 14-17, 1978, Naunyn-Schmiedeberg's Arch. Suppl. to Vol. 302, R 43, 1978

Kromer, W., C. Fischer, H. Teschemacher, V. Höllt, C. Gramsch. Extracts of uterine tissue from pregnant animals stimulate endorphin release from anterior pituitary in vitro. 7th International Congress of Pharmacology, Paris, France, July 16-21, 1978

Kromer, W., H. Teschemacher, C. Fischer, V. Höllt, R. Schulz, K.H. Voigt. Indication for a possible role of endorphins in pregnancy. International Narcotic Research Club, Noordwijkerhout, The Netherlands, July 23-27, 1978

Kromer, W., C. Fischer, K. Csontos, V. Höllt, H. Teschemacher. Indication for a role of endorphins in pregnancy or birth. II European Neurosciences Meeting, Florence, Italy, September 5-8, 1978

Kromer, W., W. Pretzlaff, E. Scheiblhuber. In vitro evidence for an involvement of intestinal endorphins in the control of peristalsis in the guinea pig ileum. Comparison to rabbit, rat, cat and dog small intestine. International Narcotic Research Club, North Falmouth, Massachusetts, USA, June 11-15, 1979

Kromer, W., W. Pretzlaff. Naloxone enhances peristalsis in the guinea pig small intestine in vitro. Third Congress of the Hungarian Pharmacological Society, Budapest, Hungary, August 22-25, 1979

Kromer, W., W. Pretzlaff, E. Scheiblhuber. In vitro evidence for a participation of intestinal endorphins in the control of peristalsis. Herbsttagung Deutsche Pharmakologische Gesellschaft, München, September 3-6, 1979. Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 308, R 40, 1979

Kromer, W., W. Pretzlaff. In vitro evidence for an involvement of endorphinergic mechanisms in the control of peristalsis in the guinea pig ileum. Third European Neuroscience Meeting, Rome, Italy, September 11-14, 1979, Neuroscience Letters, Suppl. 3, S 201, 1979

Kromer, W., E. Scheiblhuber, C. Lachenmaier. Antagonism of an intrinsic opioid mechanism by calcium in the guinea pig isolated ileum. Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, March 18-21, 1980, Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 311, R 64, 1980

Kromer, W., R. Woinoff, H. Schmidt, C. Lachenmaier. Influence of somatostatin and cholecystokinin upon intestinal peristalsis in vitro. Herbsttagung Deutsche Pharmakologische Gesellschaft, Lübeck-Travemünde, September 16-18, 1980 Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 313, R 26, 1980

Kromer, W., H. Schmidt, R. Woinoff. Characterization of an intrinsic opioid mechanism in the isolated guinea pig ileum. Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, March 10-13, 1981, Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 316, R 246, 1981

Kromer, W., H. Schmidt, V. Höllt. Intestinal opioids may modulate the action of acetylcholine on peristalsis in vitro. Release studies point to a possible role for dynorphin in the control of peristalsis. International Narcotic Research Club, Kyoto, Japan, July 26-30, 1981

Kromer, W., N. Steigemann. Differential involvement of opioid receptors in the modulation of peristalsis compared to longitudinal muscle contractions in the isolated guinea pig ileum. Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, March 16-19, 1982, Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 319, R 72, 1982

Kromer, W., H. Hannemann, K.-Fr. Sewing, N. Steigemann, W. Vivell, U. Wießenborn. Relative potencies of atropine and pirenzepine in antagonizing cholinergic stimulation of guinea pig parietal cell H+-secretion and intestinal motility in vitro. Herbsttagung Deutsche Pharmakologische Gesellschaft, Wien, September 20-23, 1982, Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 321, R 217, 1982

Kromer, W., B. Skowronek, H. Stark, S. Netz. Is gastric acid secretion modulated by a peripheral opioid mechanism? Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, March 14-18, 1983, Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 322, R 53, 1983

Kromer, W., H. Stark, B. Skowronek. Modulation of acid secretion by opioid receptors in isolated guinea pig parietal cells. International Narcotic Research Club, Garmisch-Partenkirchen, June 26 - July 1, 1983

Kromer, W., S. Netz, P. Schröder, I. Hiller. Further evidence that opioids modulate gastric acid secretion at the parietal cell level. Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, March 13-16, 1984, Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 325, R 56, 1984

Bohnenkamp, W., W. Kromer, K. Heintze. The relative effect of gastric acid inhibitiors on intragastric pH and total acid output in the dog. World Congress of Gastroenterology, Sao Paulo, Brasil, September 19-21, 1986

Bohnenkamp, W., M. Eltze, K. Heintze, W. Kromer, R. Riedel, A. Simon. Antisecretory and antiulcer activity of B 831-56, an H+/K+-ATPase inhibitor. World Congress of Gastroenterology, Sao Paulo, Brasil, September 19-21, 1986


Postius, S., U. Krüger, U. Bräuer, K. Heintze, W. Kromer. Determination of gastric bicarbonate secretion without inhibition of acid secretion: physiologic significance of CO2 back diffusion? Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, March 10-13, 1987, Naunyn-Schmiedeberg's Arch. Pharmacol. Suppl. to Vol. 335, R 68, 1987


Kromer, W., S. Postius, K. Heintze. Pentagastrin potentiation of carbachol induced gastric acid secretion in the Heidenhain pouch dog. Abstract vol. 10th International Congress of Pharmacology, O 140, Sydney, Australia, August 23-28, 1987


Schürer-Maly, C.-C., B. Flogerzi, L. Varga, W. Inauen, W. Kromer*, F. Halter. Regulation of plasma gastrin release during H+/K+-ATPase treatment in the rat. European Gastro Club, Erlangen Oct. 16-17, 1987 (* speaker)


Kromer, W., E. Baron, W. Bohnenkamp, K. Heintze, W.A. Simon. A site of gastric antisecretory action of telenzepine distinct from parietal cell- and neuronal muscarinic receptors. Frühjahrstagung Deutsche Pharmakologische Gesellschaft, Mainz, 08.-11. März 1988; Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 337, R 80, 1988


Kromer, W., S. Gönne. An acid-independent antiulcer effect of M1-antimuscarinics against cysteamine-induced ulcers in the rat duodenum. 6th International Conference on Experimental Ulcer, Jerusalem, Aug. 28-31, 1988; Dig. Dis. Sci. 33, 904, 1988


Kromer, W., E. Baron, M. Beinborn, M. Eltze, W.A. Simon. Histamine-liberating cells as a target of telenzepine in the mouse stomach in vitro. XIII International Congress of Gastroenterology, Rome, Sept. 4-10, 1988; Gastroenterology International, 1, Suppl. 1, 61, 1988


Kromer W., E. Baron, M. Beinborn, M. Eltze. Telenzepine inhibits acid secretion in the mouse stomach by blocking muscarinic M1-receptors distinct from ganglionic M1-receptors. American Gastroenterological Association, Digestive Disease Week 1989, Washington, D.C., Gastroenterology, Suppl. to Vol. 96, A 274, 1989


Postius, S., U. Bräuer, W. Kromer. Determination of the duration of action of gastric antisecretory drugs by 24 hour pH-metry in the dog. American Gastroenterological Association, Digestive Disease Week 1989, Washington D.C., Gastroenterology, Suppl. to Vol 96, A 397, 1989


Postius, S., U. Bräuer, U. Krüger, W. Kromer. Determination of gastric bicarbonate secretion in vivo without prior inhibition of acid secretion. FASEB Summer Conferences, Copper  Mountains, Colorado, USA, 02.-07. July 1989


Postius, S., R. Riedel, M.E. Parsons, W. Kromer. Gastric antisecretory studies in rat and dog on the novel, potent H+/K+ -ATPase inhibitor BY 1023/SK&F 96022. The Netherlands Society of Gastroenterology, Amsterdam, June 21-24, 1989


Kromer, W. Function of endogenous opioids in the gastrointestinal tract. Symposium on Advances in Opioid Research, Schloß Ringberg, West-Germany, July 2-5, 1989; invited review


Kromer, W., E. Baron, R. Boer, M. Eltze. Histamine-liberating cells in the mouse isolated stomach may bear muscarinic M1-receptors. 4th International Symposium on Subtypes of Muscarinic Receptors, Wiesbaden, W-Germany, July 20-22, 1989


Kromer, W. Kappa opioid receptors control reflex peristalsis in the guinea pig isolated ileum. Frühjahrstagung Deutsche Gesellschaft für Pharmakologie und Toxikologie, Mainz, 13.-16. März 1990, Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 341, R 71, 1990


Kromer, W. Is vagal (field) stimulation of gastric acid secretion mediated by M1 or non-M1 receptors? Frühjahrstagung Deutsche Gesellschaft für Pharmakologie und Toxikologie, Mainz, 12.-15. März 1991, Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 343, R 299, 1991.


Postius, S., W. Kromer, U. Bräuer, D. Hauschke, L. Fransson. Pantoprazole, a substituted benzimidazole, gains antisecretory efficacy if administered under conditions of strong gastric acid secretion in the dog. American Gastroenterological Association, Digestive Disease Week 1991, New Orleans, May 19-22, 1991, Gastroenterology, Suppl. to Vol. 100/5, A 143, 1991.


Beinborn, M., J. Nishitani, W. Kromer, M.M. Wolfe. Expression of muscarinic receptors in the dog gastric mucosa. American Gastroenterological Association, Digestive Disease Week 1991, New Orleans, May 19-22, 1991, Gastroenterology, Suppl. to Vol. 100/5, A 33, 1991


Kromer, W., S. Postius, R. Riedel, W.A. Simon, G. Hanauer, U. Brand, S. Gönne, M.E. Parsons. The substituted benzimidazole pantoprazole potently inhibits gastric acid secretion but lacks relevant cytochrome P450 interactions. American Gastroenterological Association, Digestive Disease Week, New Orleans, May 19-22, 1991, Gastroenterology, Suppl. to Vol. 100/5, A 102, 1991


Kromer, W., B. Heller. Voltage clamp experiments suggest both inhibitory and excitatory modulation of chloride secretion in the guinea pig colonic mucosa by opioid receptors. American Gastroenterological Association, Digestive Disease Week 1992, San Francisco, May 10-13, 1992, Gastroenterology, Suppl. to Vol. 102, A741, 1992


Kromer, W., B. Heller. Opioids and opioid receptors of the gastrointestinal tract and their function in motility and chloride transport. International symposium on "New perspectives in infant nutrition", Antwerp, Belgium, May 31 - June 2, 1992


Kromer, W., B. Heller. The opioid system modulates PGE1 plus theophylline-stimulated chloride secretion in the guinea pig colonic mucosa in a dual fashion. American Gastroenterological Association, Digestive Disease Week 1993, Boston, May 16-19, 1993, Gastroenterology, Suppl. to Vol. 104/4, A257, 1993


Postius, S., U. Bräuer, W. Kromer. Superior antisecretory profile of the novel reversible gastric proton pump inhibitor BY841, compared to ranitidine. American Gastroenterological Association, Digestive Disease Week 1995, San Diego, May 14-17, 1995, Gastroenterology, Suppl. to Vol. 108/4, A194, 1995


Postius, S., U. Bräuer, W. Kromer. Superior antisecretory profile of the novel acid pump antagonist BY841, compared to ranitidine. 4th United European Gastroenterology Week 1995, Berlin, September 17-21, 1995, Gut 37, Suppl. 2, A135, 1995


Wurst, W., W. Kromer, K. Zech, R. Fischer, M. Hartmann. Management of acid related diseases - focus on pantoprazole. XXV. Cesky a Slovensky Gastroenterologicky Kongres, Hradec Kralové 28.-30. zari 1995


Kolb, S., S. Postius, W. Kromer. Helicobacter felis needs steady low pO2 and low acidity for optimal growth in vitro. AGA-Meeting San Francisco, May 19-22, 1996, Gastroenterology 110 (Suppl.), A159, 1996


Postius, S., B. Kress, S. Störzbach, S. Kolb, B. Hornig, W. Kromer. Functional changes during emergence of Helicobacter felis coccoids in the stationary growth phase. AGA-Meeting San Francisco, May 19-22, 1996, Gastroenterology 110 (Suppl.), A232, 1996


Postius, S., S. Störzbach, W. Kromer. Intracellular availability of urea determines apparent urease activity in intact Helicobacter felis. AGA-Meeting San Francisco, May 19-22, 1996, Gastroenterology 110 (Suppl.), A232, 1996


Stoeck, M., W. Kromer, V. Gekeler. Characterization of the production of interleukin-15 (IL-15) by epithelial cell lines. 27th Annual Meeting of the Deutsche Gesellschaft für Immunologie, Universität Hamburg, September 26-28, 1996


Postius, S., B. Hornig, S. Kolb, W. Kromer. Attenuated cellular functions and reduced DNA-content in Helicobacter felis upon coccoid transformation. 9th European Helicobacter pylori Study Group, Copenhagen, October 16-19, 1996, Gut 39 (Suppl.), A78, 1996


Postius, S., S. Störzbach, W. Kromer. Intracellular access of urea determines apparent urease activity in intact Helicobacter felis. 9th European Helicobacter pylori Study Group, Copenhagen, October 16-19, 1996, Gut 39 (Suppl.), A78, 1996


Postius, S., U. Bräuer, W. Kromer. The acid pump antagonist (APA) B9106-086 causes a stronger and more reliable pH-elevation in the gastric mucus-layer than ranitidine. AGA-Meeting Washington, May 11-14, Gastroenterology 112/4, Suppl., A261, 1997


Stoeck, M., W. Kromer, V. Gekeler. Characterization of the production of IL-15 mRNA and protein by the human lung carcinoma cell line A549. 13th European Immunology Meeting, Amsterdam, June 22-25, 1997


Postius, S., U. Bräuer, W. Kromer. Faster, stronger and more reliable pH-elevation in the gastric mucus-layer by the acid pump antagonist (APA) B9106-086 than by ranitidine in the fistula dog: Impact for efficacy of antibiotics? Gut 41, Suppl. 1, A90, 1997


FURTHER LECTURES & INTERVIEWS

Lectures in pharmacology for medical students at Hannover Medical School

Neue Protonenpumpen-Inhibitoren: Wohin geht die pharmakologische Entwicklung nach der Einführung von Omeprazol? Invited lecture at the Clinic II of Internal Med. of Munich Technical University, July 25, 1991

Allergien im Vormarsch? Public lecture invited by BPI, Graf-Zeppelin-Haus Friedrichshafen, Nov. 06, 1992

Neue pharmakologische Erkenntnisse zur antidiarrhoischen Wirkung von Opioiden. Invited lecture at the Institute of Pharmacology, Kiel University, Febr. 25, 1993

Grundlagen und aktuelle Aspekte der Entwicklung von Hemmstoffen der Protonenpumpe des Magens. Invited lecture at the Clinic of Internal Med., Kiel University, Febr. 26, 1993

Wirkmechanismus und substanzspezifische Eigenschaften substituierter Benzimidazole (Protonenpumpen-Hemmer): 14 Lectures for practising internal specialists between Oct. 1994 and April 1998

PPIs and APAs: Some basic aspects. Lecture for an international assembly of Gastroenterologists, Febr. 22, 1996, Konstanz

Preclinical properties of pantoprazole: Achievements in proton pump inhibition. Lecture for Gastroenterologists on April 04, 1996, Athens, Greece

Acid pump antagonists: Basic and clinical aspects. Two Symposium Lectures on the occasion of the 6th World Conference of Clinical Pharmacology and Therapeutics, Aug. 4-9, 1996, Buenos Aires and Rosario, Argentina

Profile of the new PPI pantoprazole: special drug properties and clinical efficacy. Lecture on June 08, 1997 at the Annual Conference of the Polish Association of Gastroenterologists, Warschau, Poland

Pharmacology of gastric proton pump inhibitors, Lecture on Jan. 22, 1999, Palma de Mallorca, Spain

Die pH-abhängige Aktivierung von Protonenpumpeninhibitoren als Grundlage ihrer Organselektivität, Lecture on Sept. 24, 1999, Graz, Austria

 Pharmacological properties and special aspects of PPIs, Lecture on Sept. 28, 1999, Cordoba, Argentina


Interview by ARS Medici on Pantoprazole, Pharma Forum 18, 2000


Interview by Medical Tribune (Swizerland) 36 of Sept. 08, 2000, Inter Medical Report

 Sind Protonenpumpenhemmer (PPIs) bei gleicher Dosierung auch gleich wirksam? Pharmakologische Grundlagen der Wirkstärken und pH-Selektivitäten der PPIs, Lecture on April 01, 2000, Madrid, Spain; Lecture on May 13, 2000, St. Petersburg, Russia


The relative efficacies of gastric proton pump inhibitors (PPIs) on a mg basis, Lecture at the Sysmposium 'Highlights of Gastroenterology', April 14, 2000, Eilat, Israel

Klinische Pharmakologie der PPIs: Gleiche Dosis, gleiche Wirkung?; Lectrue at the Symposium "Langzeitige Säuresuppression: Nutzen und Risiken" on the occasion of the 34th Annual Conference of the ÖGGH and the 29th Congress of the Association of the Bavarian Gastroenterologists, Oct. 25, 2001, Salzburg, Austria

Relative efficacies of PPIs: Their clinical and pharmacological basis; Symposium lecture on Dec. 01, 2001, Brussels, Belgium