Born in 1943. Studies of human medicine. State examination in 1972. In 1973, Medical Doctor from Würzburg University (Institute of Pharmacology and Toxicology), and lisence to practise medicine. Clinical experience from different hospitals between 1972 and 1975. Since 1976, research scientist at the Institute of Pharmacology and Toxicology of Munich University. During this time cooperation with the Department of Neuropharmacology at the Max-Planck-Institute of Psychiatry, Munich. 1980 lisence as a specialist in Pharmacology and Toxicology. 1981 Postdoctoral lecturing qualification for Pharmacology and Toxicology (Dr. med. habil.). 1982 Appointment (permanent) as a Professor of Pharmacology at Hannover Medical School, Germany. 1984 Sabbatical at the National Institute for Medical Research, Division of Physical Biochemistry, Mill Hill, London, UK. 1985 Head of Department Pharmacology-Gastroenterology at Altana Pharma AG Konstanz, Germany (now Takeda). 1987 Appointment as an Extraordinary Professor of Pharmacology (apl. Prof.) at Hannover Medical School. 1991 Lisence as a specialist in Clinical Pharmacology. Medical expert opinions, both clinical and preclinical. During professional life member of the American Gastroenterological Association (AGA), the German Pharmacological and Toxicological Association, the International Narcotic Research Club, and the Editorial Board of the international journal 'Pharmacology'.
Electromyographic and temperature measurements in the contracted human skeletal muscle. Pharmacological, physiological and biochemical studies on endogenous opioid functions, including pain control, intestinal motility and secretion, gastric secretion, and release of endogenous opioids. Voltage clamp experiments on the opioid receptor subtypes involved in the control of intestinal chloride secretion. Muscarinic receptor binding studies in the rat cerebral cortex and heart. Characterization of muscarinic receptors in the isolated mouse stomach. Participation in the development of irreversible and reversible gastric proton pump inhibitors, in particular pantoprazole. Participation in microbiological sudies on Helicobacter pylori.